LAISHA · DRAVYAGUNA

Kalmegha

कालमेघ

Andrographis paniculata (Burm.f.) Nees

Acanthaceae · Andrographis

Benefits & side effects

TRADITIONAL VIEW, WITH SAFETY LIMITS

What the texts say Kalmegha does

What the evidence says. Traditional use is extensive and long recorded. Modern clinical evidence is limited.

Side effects and limits

Avoid or ask first: Pregnancy.; Anyone trying to conceive, in light of the above.; Autoimmune conditions, given its immune-stimulating activity.; and more below.

A traditional classification, not a recommendation. The full safety record is below.

Stands in 3 groups

A Samhita can only be read forwards, from the group to its members. This is the same list read backwards.

Photographs

Matra and anupana

AS THE CLASSICAL TEXTS AND THE API PRESCRIBE

Churna1–3 g
Kwatha20–40 ml
Swarasa5–10 ml
AnupanaUshnodaka · Madhu
KalaAdhobhakta

Intensely tikta; the matra is small because the bitterness itself limits it.

Reported from Sharangadhara Samhita and the Ayurvedic Pharmacopoeia of India. Laisha states what the texts prescribe; it does not recommend. No quantity here is adjusted for a particular person — not for agni, koshtha, bala, age, pregnancy, kidney or liver function, or anything already being taken.

Pharmacopoeial standard

Ayurvedic Pharmacopoeia of India, Part I

MarkerAndrographolide
AssayNot less than 1.0 per cent
Total ashTotal ash not more than 12 per cent
Acid-insoluble ashNot more than 2 per cent
Alcohol-soluble extractiveAlcohol-soluble extractive not less than 10 per cent
Water-soluble extractiveWater-soluble extractive not less than 14 per cent
Foreign matterForeign matter not more than 2 per cent

Andrographolide is the bitter principle; a sample that is not intensely bitter will not meet the limit.

These are the pharmacopoeial limits for the article, not a test Laisha has run on anything. They are here so a practitioner can ask a supplier for a certificate of analysis and know what the numbers on it should say.

Rasapanchaka

Rasa
Tikta
Guna
LaghuRuksha
ViryaSheeta
VipakaKatu
PrabhavaThe texts treat kalmegha as acting on the liver and in fever, and it is the bitter herb of choice where nimba is not to hand.
DoshakarmaKaphapittahara. Being ruksha and sheeta it increases vata.

A single rasa, tikta, and it is the standard example of an extremely tikta dravya. Sheeta virya and katu vipaka.

Karma and part used

JwaraghnaKamalaharaDeepanaKrimighnaRaktashodhanaKushthaghna

These are the actions the classical texts record. They are statements about what the tradition holds, and this library does not restate them as findings about a human body.

Upayukta angaPanchanga (the whole plant)
Patra (the leaf)
Why it mattersThe whole herb, collected at flowering, is the article. The leaf carries the most andrographolide.

Paryaya

BhunimbaYavatiktaKiratatiktaVishwambharaMahatikta

Bhunimba means earth-neem, because it is as bitter as nimba without being a tree. Mahatikta, the great bitter, says it plainly. The paryaya Kiratatikta is shared with Swertia chirata, which is a different plant, and that overlap is the source of real confusion.

Names, by language

EnglishKing of bitters
SinhalaHeen kohomba
NepaliKalmegh
HindiKalmegh
KannadaNelabevu
TamilNilavembu
TeluguNelavemu
MalayalamKiriyathu
MarathiOli kiryata
GujaratiKariyatu
BengaliKalmegh
PunjabiChirayata
OdiaBhuinimba
UrduKalmegh

Classical references

Bhavaprakasha Nighantu
Guduchyadi Varga
Gives the rasa, guna, virya and vipaka of bhunimba.
Charaka Samhita
Sutrasthana, chapter 4 (Shadvirechanashatashritiya)
Named among the dravya of the chapter.
Sushruta Samhita
Sutrasthana, chapter 38 (Dravyasangrahaniya)
Included among the dravya grouped by action.

Rasa, guna, virya, vipaka and karma are recorded as the classical texts give them, with the text and section named so a student can open the book and check. Where an exact chapter and verse could not be confirmed, this library names the section rather than inventing a number.

Formulations it appears in

KalmeghasavaA fermented preparation named for the dravya.
Nilavembu KudineerKalmegha is the principal dravya of this Siddha formulation, widely used in fevers.
Bhunimbadi KwathaNamed for the dravya.

Adulterants and substitutes

Swertia chirata, Kiratatikta, shares a paryaya with this plant and is a different family entirely; the two are sold interchangeably as chirayata across north India, and Swertia is scarcer and dearer, so the substitution runs from cheap to dear. Both are intensely bitter, so taste does not separate them.

Identity

Matched live against the GBIF backbone on 28 September 2026 at 99 per cent confidence. Called the king of bitters, and among the most intensely bitter plants used anywhere — the taste is the identification.

A WAY TO REMEMBER IT

Andrographis is andros (man) + graphis (a pencil or brush) — the anthers. Paniculata means the flowers are in a panicle. Kal-megha means dark cloud, for the bitterness and the colour.

What the tradition holds

Kalmegha is described in the Bhavaprakasha Nighantu as bhunimba. That is what the tradition holds and where it is written down, not a finding about what the herb does in a body.

Constituents. The herb carries diterpene lactones, principally andrographolide, which is what commercial extracts are standardised to and what makes it so bitter.

What the evidence says

StatusTraditional use is extensive and long recorded. Modern clinical evidence is limited.
SuggestedHealth Canada publishes monographs covering Ayurvedic ingredients and permits specific traditional-use claims, which reflects a regulator accepting a documented tradition rather than a body of clinical trial evidence.
Not establishedThere is not enough good clinical evidence to establish an effect on any named health condition. Long traditional use is not a substitute for that evidence, and this library does not present it as one.
The honest gapPublished work uses standardised andrographolide extracts of a strength the crude herb does not reach.

Safety

Several cautions and they are documented rather than precautionary. It is used in fever, and fever in India includes malaria, dengue and typhoid — a diagnosis, not a herb, is the first step. Andrographis has documented effects on fertility in animal studies, which is why it is contraindicated in pregnancy. Allergic reactions including anaphylaxis have been reported. It may lower blood sugar and blood pressure and can add to medicines doing the same, and it may stimulate the immune system, which matters for anyone on medicines that suppress it. Anyone on medication, pregnant, or managing a diagnosed condition should speak to a doctor or a qualified practitioner first.

Side effectsLoss of appetite and nausea from the bitterness
Digestive upset
Headache
Allergic rash
ContraindicationsPregnancy.
Anyone trying to conceive, in light of the above.
Autoimmune conditions, given its immune-stimulating activity.
Known allergy to plants of the Acanthaceae family.
InteractionsAntihypertensives and antidiabetic medicines — additive lowering.
Anticoagulants and antiplatelets — antiplatelet activity reported for andrographolide.
Immunosuppressants — immunostimulant direction opposes them.
Pregnancy and breastfeedingNot to be used in pregnancy or breastfeeding.
Reported allergic reactions including anaphylaxisAllergic reactions to Andrographis preparations, including anaphylaxis, are recorded in the published literature and in regulatory reporting.
Documented effects on fertility in animal studiesAndrographis has shown antifertility activity in animal studies, which is the basis for the pregnancy contraindication and for caution in anyone trying to conceive.

Growing it

ClimateTropical; an annual herb, cultivated and also wild.
SoilWell-drained ground.
PlantingGrown from seed as a rainy-season annual.
HarvestThe whole herb is cut at flowering, when andrographolide is highest, and dried in shade.
What is not statedThis library has not verified region-specific spacing, variety and yield figures against a named agricultural authority for every growing country, and does not state them rather than guessing.

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What this is not

Sources

GBIF Backbone Taxonomy species-match record for Andrographis paniculata (Burm.f.) Nees
Global Biodiversity Information Facility (GBIF) · read 2026-09-28
Confirming live, rather than from memory, the accepted botanical name and family behind the Sanskrit name.
https://api.gbif.org/v1/species/match?name=Andrographis%20paniculata
The Ayurvedic Pharmacopoeia of India — Kalmegha (Andrographis paniculata)
Pharmacopoeia Commission for Indian Medicine and Homoeopathy, Ministry of Ayush, Government of India · read 2026-09-28
The official Indian pharmacopoeial standing of the dravya and the identity of the part used as the pharmacopoeial article.
https://pcimh.gov.in/
Compendium of Monographs — Natural Health Products
Health Canada, Natural and Non-prescription Health Products Directorate · read 2026-09-28
A regulator outside India that publishes monographs covering Ayurvedic ingredients — used for the safety framing, and for the line between a permitted traditional-use claim and clinical evidence.
https://www.canada.ca/en/health-canada/services/drugs-health-products/natural-non-prescription/applications-submissions/product-licensing/compendium-monographs.html
Classical matra by dose form
Sharangadhara Samhita, Madhyama Khanda
The classical quantity for each dose form, as the standard reference gives it. Sharangadhara is where Ayurveda's dose forms and their measures are set out, and it is what every Dravyaguna textbook reproduces.
https://niimh.nic.in/ebooks/esharangadhara/
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