LAISHA · DRAVYAGUNA

Yashtimadhu

यष्टिमधु

Glycyrrhiza glabra L.

Fabaceae · Glycyrrhiza

One name, more than one plant

Three species are used: Glycyrrhiza glabra, Glycyrrhiza uralensis and Glycyrrhiza inflata. Products may contain any of them. Confirmed live against the GBIF backbone taxonomy.

Benefits & side effects

TRADITIONAL VIEW, WITH SAFETY LIMITS

Hindi name: Mulethi

What the texts say Yashtimadhu does

What the evidence says. Weak. NCCIH states there is not enough high-quality evidence to clearly support its use for any health condition.

Side effects and limits

Avoid or ask first: Avoid if you have high blood pressure, heart disease or kidney disease, unless a doctor says otherwise.; Avoid large amounts in pregnancy.

A traditional classification, not a recommendation. The full safety record is below.

Stands in 21 groups

A Samhita can only be read forwards, from the group to its members. This is the same list read backwards.

Photographs

Matra and anupana

AS THE CLASSICAL TEXTS AND THE API PRESCRIBE

Churna2–4 g
Kwatha50–100 ml
AnupanaDugdha · Ghrita · Madhu
KalaAdhobhakta

Time-limited by design: prolonged use causes sodium and water retention with potassium loss. EMA/HMPC gives roughly 100 mg glycyrrhizin a day and no more than 4–6 weeks without supervision.

Reported from Sharangadhara Samhita and the Ayurvedic Pharmacopoeia of India. Laisha states what the texts prescribe; it does not recommend. No quantity here is adjusted for a particular person — not for agni, koshtha, bala, age, pregnancy, kidney or liver function, or anything already being taken.

Pharmacopoeial standard

Ayurvedic Pharmacopoeia of India, Part I

MarkerGlycyrrhizin
AssayNot less than 4.0 per cent
Total ashTotal ash not more than 10 per cent
Acid-insoluble ashNot more than 2 per cent
Alcohol-soluble extractiveAlcohol-soluble extractive not less than 10 per cent
Water-soluble extractiveWater-soluble extractive not less than 20 per cent
Foreign matterForeign matter not more than 2 per cent

Glycyrrhizin is both the marker and the hazard, which is why this per cent matters more than most: the EMA ceiling on daily glycyrrhizin is stated in the matra block above, and it is only meaningful if you know what fraction of the drug is glycyrrhizin. A sample assaying at twice the minimum delivers twice the exposure at the same matra.

These are the pharmacopoeial limits for the article, not a test Laisha has run on anything. They are here so a practitioner can ask a supplier for a certificate of analysis and know what the numbers on it should say.

Rasapanchaka

Rasa
Madhura
Guna
GuruSnigdha
ViryaSheeta
VipakaMadhura
PrabhavaThe texts place yashtimadhu among the jivaniya, the group named for sustaining life, and among the varnya dravya.
DoshakarmaVatapittahara. Being guru and snigdha it increases kapha, which the texts state plainly.

A single rasa, madhura, and one of the clearest examples of it in the materia medica.

Karma and part used

JivaniyaVarnyaKanthyaChakshushyaVrishyaShothahara

These are the actions the classical texts record. They are statements about what the tradition holds, and this library does not restate them as findings about a human body.

Upayukta angaMula (the root and stolon)
Why it mattersThe root is used. Some products are deglycyrrhizinated, meaning the component responsible for most of the harm has been removed — and a label that does not say so should not be assumed to be.

Paryaya

MadhukaKlitakaYashtyahvaMadhuyashti

Yashti means a stick and madhu means sweet: the sweet stick. The name is a description of the article as it is sold.

Names, by language

EnglishLiquorice
NepaliJethimadhu
ArabicSus
HindiMulethi
KannadaJestamadhu
TamilAthimadhuram
TeluguAtimadhuram
MalayalamIratimadhuram
MarathiJeshthamadh
GujaratiJethimadh
BengaliJashtimadhu
PunjabiMulathi
OdiaJatimadhu
UrduMulethi

Classical references

Charaka Samhita
Sutrasthana, chapter 4 (Shadvirechanashatashritiya)
Yashtimadhu heads the Sandhaniya dashemani — the group named for healing and union. The Jivaniya dashemani is headed by Jivanti, not by yashtimadhu; the two are easy to confuse because both act on depletion.
Bhavaprakasha Nighantu
Haritakyadi Varga
Gives the rasa, guna, virya and vipaka of yashtimadhu.
Sushruta Samhita
Sutrasthana, chapter 38 (Dravyasangrahaniya)
Included among the dravya grouped by action.

Rasa, guna, virya, vipaka and karma are recorded as the classical texts give them, with the text and section named so a student can open the book and check. Where an exact chapter and verse could not be confirmed, this library names the section rather than inventing a number.

Formulations it appears in

Yashtimadhu ChurnaThe plain powdered root.
Jivaniya Gana preparationsYashtimadhu heads the group these are built on.
Brahma RasayanaAmong the dravya of the formulation.

Adulterants and substitutes

Abrus precatorius, gunja, is called Indian liquorice and its root is substituted for yashtimadhu in some markets. That is a substitution worth knowing about, because Abrus seed is severely toxic; the root is not the seed, but a trade that confuses the plants is a trade that can confuse the parts. Exhausted root — already extracted for its sweetness and dried again — is the commoner and quieter adulteration.

Identity

Three species are used: Glycyrrhiza glabra, Glycyrrhiza uralensis and Glycyrrhiza inflata. Products may contain any of them. Confirmed live against the GBIF backbone taxonomy.

A WAY TO REMEMBER IT

Glycyrrhiza is glykys (sweet) + rhiza (root) — sweet root, and liquorice is the same two Greek words worn down through Latin and French. Glabra means smooth, without hairs. Yashti-madhu means sweet stick: the Sanskrit is the Greek, translated.

What the tradition holds

Licorice appears in Ayurveda as yashtimadhu and is among the most widely used plants in traditional Chinese medicine. That is what the traditions hold; it is not a finding about what the plant does in a body, and the cardiac effects described here occurred within traditional and everyday use.

What the evidence says

StatusWeak. NCCIH states there is not enough high-quality evidence to clearly support its use for any health condition.
SuggestedLimited findings: a licorice mouth rinse might reduce the size and pain of canker sores; gargling or lozenges before surgery may help prevent or lessen sore throat after intubation; preliminary evidence suggests topical gels may help eczema or burn healing; and one study indicated a mouthwash with licorice extract might improve bad breath.
Not establishedNo health condition is clearly supported by high-quality evidence.
The honest gapEvery positive finding above is topical or in the mouth. None of them is a reason to swallow licorice regularly, which is where the documented harm lies.

Safety

Glycyrrhizin can cause irregular heartbeat and cardiac arrest, especially in large amounts or over time. Even small amounts have been linked to severe effects in people with high blood pressure, heart or kidney conditions, or a high-salt diet.

Side effectsRaised blood pressure
Irregular heartbeat
ContraindicationsAvoid if you have high blood pressure, heart disease or kidney disease, unless a doctor says otherwise.
Avoid large amounts in pregnancy.
InteractionsThiazide and loop diuretics — glycyrrhizin inhibits 11-beta-hydroxysteroid dehydrogenase type 2, producing a pseudohyperaldosteronism with sodium retention and potassium loss. Added to a potassium-wasting diuretic the hypokalaemia is additive and can be severe. Check serum potassium.
Digoxin — the hypokalaemia above sensitises the myocardium to digoxin, so toxicity can appear at a digoxin level that was previously fine. This is the most dangerous interaction in this entry.
Antihypertensives — sodium and water retention opposes them and blood pressure may rise on a stable dose.
Corticosteroids — glycyrrhetinic acid slows cortisol breakdown and potentiates the mineralocorticoid effect.
Potassium-depleting laxatives and prolonged stimulant laxative use — additive potassium loss.
Warfarin — case reports of altered INR; monitor if the two are combined.
Pregnancy and breastfeedingNCCIH states that consuming licorice in large amounts during pregnancy is unsafe and has been associated with early delivery. The quantity at which that was observed is published by the regulator; this library states the hazard and not the number, because a number here reads as a threshold that is safe to approach
Irregular heartbeat and cardiac arrestNCCIH states that glycyrrhizin can cause serious adverse effects such as irregular heartbeat and cardiac arrest, especially when consumed in large amounts or in the long term.
Severe effects at small amounts in vulnerable peopleEven small amounts of glycyrrhizin have been linked to severe adverse effects in people who consume a lot of salt, in people with hypertension, and in people with heart or kidney conditions.

Growing it

ClimateA perennial legume of warm temperate regions with long dry summers.
SoilDeep, loose, free-draining and fertile soil. The crop is the root, so depth matters.
PlantingGrown from root divisions or from seed, and it takes several years before roots are worth lifting.
HarvestRoots are lifted after several seasons of growth, then washed and dried.
What is not statedLaisha holds no sourced yield, spacing or cost figure for licorice and offers none.

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What this is not

Sources

Licorice Root
National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health · read 2026-09-21
The three botanical species used; the statement that there is not enough high-quality evidence to clearly support any health condition; the limited findings for canker sores, post-intubation sore throat, topical eczema and burn healing, and bad breath; glycyrrhizin as the component responsible; irregular heartbeat and cardiac arrest in large amounts or long term; severe effects from small amounts in people with high salt intake, hypertension, or heart or kidney conditions; the in large amounts, pregnancy warning and preterm delivery risk; and the reported corticosteroid interaction.
https://www.nccih.nih.gov/health/licorice-root
Glycyrrhiza glabra L. — GBIF Backbone Taxonomy
Global Biodiversity Information Facility (GBIF), Copenhagen · read 2026-09-21
The accepted botanical name with author and placement in Fabaceae, matched live at 98 per cent confidence, usage key 2965732.
https://api.gbif.org/v1/species/match?name=Glycyrrhiza%20glabra
The Ayurvedic Pharmacopoeia of India — Yashtimadhu (Glycyrrhiza glabra L.)
Pharmacopoeia Commission for Indian Medicine and Homoeopathy, Ministry of Ayush, Government of India · read 2026-09-28
The official Indian pharmacopoeial standing of the dravya and the identity of the part used as the pharmacopoeial article.
https://pcimh.gov.in/
Classical matra by dose form
Sharangadhara Samhita, Madhyama Khanda
The classical quantity for each dose form, as the standard reference gives it. Sharangadhara is where Ayurveda's dose forms and their measures are set out, and it is what every Dravyaguna textbook reproduces.
https://niimh.nic.in/ebooks/esharangadhara/
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