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ASRB NET Advanced Design of Experiments (PhD): practice questions

ASRB NET - Agricultural Statistics (and Computer Application / Bioinformatics) · India · Agricultural Scientists Recruitment Board (ICAR)

Original practice questions written to the published syllabus · not past papers
10worked here, free
84written to this exam in this subject
10syllabus units

What this subject covers

Research-level design theory as practised at IASRI and Rothamsted: optimality of block and row-column designs, designs for correlated errors and neighbour effects, designs for bioassays and diallel crosses, supersaturated and computer-search designs, and designs for computer experiments.

In the exams: AICE-JRF Ag Stat Unit 4 (present at depth); ASRB ARS Ag Stat interview (reported); the research frontier for PhD scholars

What ASRB NET asks from it

ASRB NET / ARS Agricultural Statistics (reported)

Research-level design questions: optimality, neighbour-balanced and row-column designs, bioassay designs, orthogonal arrays and computer-generated designs.

Where the 84 questions fall

How our questions for ASRB NET spread across the units of Advanced Design of Experiments (PhD). Difficulty: 13 easy, 47 medium, 24 hard.

Optimality theory of block designs: universal optimality10
Designs for bioassays and parallel-line assays9
Supersaturated and screening designs9
Designs for computer experiments: Latin hypercube sampling9
Row-column designs and their analysis8
Designs with neighbour effects and correlated errors8
Designs for diallel crosses and for factorial treatments in blocks8
Orthogonal arrays and their construction8
Computer-aided search for efficient designs8
Robustness of designs to missing observations7

10 practice questions, worked

Choose an answer, then open the working. Each explanation says why the right answer is right and why the others are not.

1 · Optimality theory of block designs: universal optimality · easy

Whenever a BIBD exists for given v, b and k, it is:

  1. Universally optimal
  2. Optimal only for E
  3. Never A-optimal
  4. Disconnected
Answer and working

A. Universally optimal

Its C-matrix is completely symmetric with maximum trace.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

2 · Optimality theory of block designs: universal optimality · medium

Which criterion minimises the average variance of elementary contrasts?

  1. D-optimality
  2. G-optimality
  3. A-optimality
  4. E-optimality
Answer and working

C. A-optimality

A minimises the sum of reciprocal eigenvalues of C (average variance); D maximises their product; E the smallest.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

3 · Row-column designs and their analysis · medium

How many error df does a connected row-column design with p = 4 rows, q = 6 columns and v = 12 treatments have?

  1. 13
  2. 8
  3. 6
  4. 4
Answer and working

D. 4

pq - p - q - v + 2 = 24 - 4 - 6 - 12 + 2 = 4.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

4 · Row-column designs and their analysis · medium

In a latinized design, what extra condition holds?

  1. Each entry once in each long field column
  2. Each entry appears twice in every block
  3. Entries are never randomised within blocks
  4. Each replicate is a complete Latin square
Answer and working

A. Each entry once in each long field column

Latinization protects against trends along the full length of the field.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

5 · Designs with neighbour effects and correlated errors · medium

What are border plots used for in circular neighbour-balanced designs?

  1. Measuring the error variance directly
  2. Testing a new treatment outside the design
  3. Holding extra replicates of the control
  4. Giving end plots their designed neighbours
Answer and working

D. Giving end plots their designed neighbours

Border plots repeat end treatments so every plot has the intended neighbours.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

6 · Designs for bioassays and parallel-line assays · medium

In a slope-ratio assay, how is relative potency estimated?

  1. Ratio of mean responses
  2. Ratio of slopes on dose
  3. Horizontal distance on log dose
  4. Difference of intercepts
Answer and working

B. Ratio of slopes on dose

Lines in dose share an intercept; potency is the slope ratio.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

7 · Designs for bioassays and parallel-line assays · medium

For quantal-response assays, where should doses be placed?

  1. Only at doses giving 100% response
  2. Around 20% to 80% expected response
  3. Only at doses giving 0% response
  4. At a single dose repeated many times
Answer and working

B. Around 20% to 80% expected response

Information about the LD50 is greatest in the middle response range.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

8 · Supersaturated and screening designs · medium

Which criterion is commonly minimised in choosing supersaturated designs?

  1. Error df (N - 1)
  2. E(s^2)
  3. Trace of C
  4. Number of levels
Answer and working

B. E(s^2)

E(s^2), the average squared inner product of column pairs (Booth and Cox), measures non-orthogonality.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

9 · Orthogonal arrays and their construction · medium

How many times does each level pair occur in two columns of OA(8, 7, 2, 2)?

  1. 2
  2. 8
  3. 4
  4. 1
Answer and working

A. 2

Each pair of columns has 2^2 = 4 level combinations, each occurring lambda = 8/4 = 2 times.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

10 · Designs for computer experiments: Latin hypercube sampling · medium

Why are computer experiments not replicated?

  1. Replication is too expensive
  2. Blocks are not available
  3. The simulator is deterministic
  4. Randomisation is impossible
Answer and working

C. The simulator is deterministic

Repeating a run gives the same output, so replication adds nothing.

Further reading: Shah and Sinha, Theory of Optimal Designs; Dey, Theory of Block Designs; Hedayat, Sloane and Stufken, Orthogonal Arrays

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Read the subject

Advanced Design of Experiments (PhD)The full study manual, free ASRB NETFormat, sections and how it has changed

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Advanced Design of Experiments (PhD) for other exams

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