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Australasian Veterinary Examination, formerly the National Veterinary Examination Veterinary Pharmacy, Prescribing Law & Medicines Regulation: practice questions

Australasian Veterinary Examination (AVE), formerly the National Veterinary Examination (NVE) · Australia / New Zealand · Australasian Veterinary Boards Council (AVBC)

Original practice questions written to the published syllabus · not past papers
10worked here, free
46written to this exam in this subject
7syllabus units

What this subject covers

Writing a lawful prescription and dispensing safely: who may prescribe, extra-label use and the cascade, withdrawal periods and MRLs, drugs prohibited in food animals, pharmacovigilance, controlled drugs and records.

In the exams: EAEVE Day One competences on prescribing, dispensing and reporting adverse reactions; WOAH Day 1 veterinary products; RCVS Day One competences (the cascade)

Where the 46 questions fall

How our questions for Australasian Veterinary Examination, formerly the National Veterinary Examination spread across the units of Veterinary Pharmacy, Prescribing Law & Medicines Regulation. Difficulty: 17 easy, 23 medium, 6 hard.

Dispensing20
Prescription writing8
Withdrawal periods7
Pharmacovigilance and adverse-event reporting6
Record keeping3
Extra-label use: US AMDUCA and the UK cascade1
Maximum residue limits1

10 practice questions, worked

Choose an answer, then open the working. Each explanation says why the right answer is right and why the others are not.

1 · Prescription writing · hard

A label reads 'Apply 1 drop OD'. The owner of a dog with an ulcer in the right eye puts one drop in the left eye once a day, reading OD as 'once daily'. What is the best prescribing practice to prevent this?

  1. Keep the abbreviation and explain it verbally at collection
  2. Use OD only for once daily and OS for every other day
  3. Write OU so that both eyes are covered whichever is meant
  4. Write the eye and the frequency in plain words, such as right eye once a day
Answer and working

D. Write the eye and the frequency in plain words, such as right eye once a day

OD means right eye (oculus dexter) to one reader and once daily to another. Plain words on the label remove the ambiguity. Treating both eyes (OU) exposes a healthy eye to a drug it does not need, and verbal explanation is forgotten.

2 · Dispensing · easy

An owner asks whether she can crush an enteric-coated tablet to hide it in food for her dog. What is the correct advice?

  1. Yes, provided the powder is mixed into a fatty food
  2. No, but it may be split into quarters without any loss of effect
  3. Yes; all tablets work the same once they have been crushed
  4. No; crushing defeats the protective enteric coating
Answer and working

D. No; crushing defeats the protective enteric coating

An enteric coating stops the tablet dissolving in the stomach, either to protect the drug from acid or to protect the stomach from the drug. Crushing or splitting defeats it. Ask for a different formulation instead.

3 · Dispensing · medium

A multi-dose injectable vial was first broached 35 days ago. Its SPC gives an in-use shelf life of 28 days. Half the liquid remains and the printed expiry date is next year. What should be done?

  1. Refrigerate it to reset the in-use shelf life for another 28 days
  2. Use it, because the printed expiry date has not yet been reached
  3. Use it for non-urgent cases only, until the printed expiry date
  4. Discard it; the in-use shelf life has ended
Answer and working

D. Discard it; the in-use shelf life has ended

Once a vial is broached, the in-use shelf life in the SPC applies, because of the risk of contamination and degradation. The printed expiry applies only to unopened product. Mark the opening date on every vial.

4 · Dispensing · medium

A horse is euthanased with an overdose of pentobarbital on a farm. Why must the carcass be disposed of securely and not left for scavengers?

  1. Leaving it exposed lets pentobarbital leach out and reach a safe level
  2. Pentobarbital residues in the carcass can kill dogs and wild scavengers that eat it
  3. Pentobarbital residues make the meat safe to eat but illegal to sell
  4. The drug breaks down into a gas that harms people near the carcass
Answer and working

B. Pentobarbital residues in the carcass can kill dogs and wild scavengers that eat it

Pentobarbital persists in the tissues of euthanased animals and has killed dogs, eagles and other scavengers (relay toxicosis). Secure burial or rendering, as local rules allow, prevents this.

5 · Dispensing · easy

5 g of a drug is dissolved and made up to 250 mL. What is the strength as % w/v?

  1. 0.2%
  2. 2%
  3. 20%
  4. 5%
Answer and working

B. 2%

% w/v = g per 100 mL. 5 g in 250 mL = 2 g in 100 mL = 2%. 20% and 0.2% are tenfold slips; 5% ignores the volume.

6 · Withdrawal periods · medium

A vet gives a calf double the labelled dose of an antibiotic. Why is the label withdrawal period no longer reliable?

  1. Withdrawal depends only on the route of administration, never on the dose
  2. A higher dose speeds up elimination, so the label withdrawal becomes too long
  3. More drug must be cleared, so residues could exceed the MRL at label time
  4. Labels always build in a margin for a doubled dose, so nothing changes at all
Answer and working

C. More drug must be cleared, so residues could exceed the MRL at label time

Withdrawal periods come from depletion studies at the labelled dose, route and duration. More drug, a longer course or a different route can leave residues above the MRL after the label time.

7 · Withdrawal periods · medium

Under Article 115 of Regulation (EU) 2019/6, a product authorised for cattle with a zero meat withdrawal is used under the cascade in turkeys. What is the minimum meat withdrawal?

  1. 1 day
  2. 7 days
  3. Zero days
  4. 28 days
Answer and working

A. 1 day

When a product with a zero withdrawal period is used in a different taxonomic family, the EU minimum is 1 day for meat. Zero is the label figure for the authorised species only; 28 days is for products not authorised in food animals.

Further reading: Regulation (EU) 2019/6, Article 115

8 · Pharmacovigilance and adverse-event reporting · easy

A farmer reports that a wormer, given correctly, no longer reduces faecal egg counts in his sheep. Is this a reportable adverse event?

  1. No; poor efficacy is a commercial matter for the seller
  2. Only if a sheep dies after treatment with the wormer
  3. Yes; lack of expected efficacy is reportable
  4. No; only reactions in the treated animals are reported
Answer and working

C. Yes; lack of expected efficacy is reportable

Veterinary pharmacovigilance includes lack of expected efficacy, which may signal resistance. Reports help regulators and companies spot emerging anthelmintic or antimicrobial resistance.

9 · Pharmacovigilance and adverse-event reporting · hard

Milk from a cow tests positive for residues above the MRL even though the farmer observed the label withdrawal period exactly. How should this be treated?

  1. As the farmer's fault, so no report to the regulator is needed
  2. As an adverse event suggesting the label withdrawal is too short
  3. As normal biological variation that needs no further action
  4. As a laboratory error, so the positive result can safely be ignored
Answer and working

B. As an adverse event suggesting the label withdrawal is too short

A residue violation after the correct withdrawal is part of the scope of pharmacovigilance in the EU and GB. Reports can lead to a review of the withdrawal period.

10 · Record keeping · easy

Under EU rules, keepers of food-producing animals must keep records of medicines bought and given. For how long at minimum?

  1. 6 months
  2. 2 years
  3. Until the animal is slaughtered
  4. 5 years
Answer and working

D. 5 years

Regulation 2019/6 requires keepers of food-producing animals to keep medicine records for at least five years, so residue investigations can trace treatments after the animal has gone.

Further reading: Regulation (EU) 2019/6, Article 108

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Read the subject

Veterinary Pharmacy, Prescribing Law & Medicines RegulationThe full study manual, free Australasian Veterinary Examination, formerly the National Veterinary ExaminationFormat, sections and how it has changed

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Veterinary Pharmacy, Prescribing Law & Medicines Regulation for other exams

RCVS Statutory Membership Examination · UKNAVLE · USA / CanadaSAVC Registration Examination · South AfricaVeterinary Council of Ireland registration exam · IrelandNational Licensure Examination for Veterinarians · NepalKenya Veterinary Board pre-registration exam · Kenya

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