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Australasian Veterinary Examination, formerly the National Veterinary Examination Veterinary Epidemiology & Zoonoses: practice questions

Australasian Veterinary Examination (AVE), formerly the National Veterinary Examination (NVE) · Australia / New Zealand · Australasian Veterinary Boards Council (AVBC)

Original practice questions written to the published syllabus · not past papers
9worked here, free
30written to this exam in this subject
12syllabus units

What this subject covers

How disease is measured, studied and controlled in populations, from incidence and prevalence to surveillance and outbreak investigation, plus the major zoonoses and One Health.

In the exams: Nepal NLEV Epidemiology & Public Health 6; SAVC epidemiology 15 and zoonoses 25; EGEL Plus epidemiology 15; ICAR AICE-JRF core group 06

Where the 30 questions fall

How our questions for Australasian Veterinary Examination, formerly the National Veterinary Examination spread across the units of Veterinary Epidemiology & Zoonoses. Difficulty: 12 easy, 14 medium, 4 hard.

Evaluation of diagnostic tests: sensitivity and specificity5
Zoonoses: rabies, brucellosis, tuberculosis and anthrax4
Outbreak investigation3
Zoonoses: leptospirosis, glanders, KFD, avian influenza and Japanese encephalitis3
Terms of disease occurrence: sporadic, enzootic, epizootic, panzootic and exotic2
Measures of disease frequency: incidence, prevalence, morbidity, mortality and case fatality2
Epidemiological study designs2
Sampling for disease surveys2
Surveillance2
Risk analysis2
One Health2
Transboundary animal diseases and WOAH1

9 practice questions, worked

Choose an answer, then open the working. Each explanation says why the right answer is right and why the others are not.

1 · Measures of disease frequency: incidence, prevalence, morbidity, mortality and case fatality · easy

During an outbreak of respiratory disease, 40 calves become ill and 6 of them die. What is the case fatality rate?

  1. 6%
  2. 17.6%
  3. 40%
  4. 15%
Answer and working

D. 15%

Case fatality = deaths / cases = 6/40 = 15%. It measures severity. Dividing deaths by the whole herd gives mortality, not case fatality; 17.6% divides by the 34 survivors (6/34).

Further reading: Thrusfield M et al., Veterinary Epidemiology, 4th ed.

2 · Surveillance · easy

A national system relies on farmers and private veterinarians to report suspect cases of disease to the veterinary authority. This is:

  1. Passive surveillance
  2. Targeted active surveillance
  3. Sentinel surveillance
  4. Participatory surveillance
Answer and working

A. Passive surveillance

Passive surveillance depends on reports initiated by others. It is continuous and cheap but misses mild or unrecognised disease. Active surveillance is initiated by the authority through planned sampling.

Further reading: Thrusfield M et al., Veterinary Epidemiology, 4th ed.

3 · Evaluation of diagnostic tests: sensitivity and specificity · medium

A test applied to 1,000 animals gives TP 90, FN 10, FP 45 and TN 855. What is the negative predictive value?

  1. 98.8%
  2. 95%
  3. 90%
  4. 66.7%
Answer and working

A. 98.8%

NPV = TN/(TN + FN) = 855/865 = 0.988. 95% is the specificity, which students often give instead; 66.7% is the PPV (90/135).

Further reading: Thrusfield M et al., Veterinary Epidemiology, 4th ed.

4 · Outbreak investigation · medium

In a feed-associated outbreak, 80 broilers received a particular batch of feed and 20 became ill. What is the attack rate among birds that received it?

  1. 20%
  2. 4%
  3. 25%
  4. 80%
Answer and working

C. 25%

Attack rate = ill / exposed = 20/80 = 25%. The value is compared with the attack rate in birds not fed that batch to implicate or exonerate it. 4% inverts the ratio (80/20 = 4).

Further reading: Thrusfield M et al., Veterinary Epidemiology, 4th ed.

5 · Zoonoses: rabies, brucellosis, tuberculosis and anthrax · medium

A healthy, vaccinated pet dog bites a person. Under the approach used in many countries, what is the standard animal-side step?

  1. Euthanase the dog immediately and test the brain in every case, whatever its vaccination status
  2. Observe the dog for 10 days; if it stays healthy it was not shedding rabies virus when it bit
  3. Vaccinate the dog again and take no further action
  4. Take a blood sample for rabies antibody and use the titre to decide on the person's treatment
Answer and working

B. Observe the dog for 10 days; if it stays healthy it was not shedding rabies virus when it bit

Dogs, cats and ferrets shed virus in saliva only shortly before signs appear, so a 10-day observation period is widely used. National rules decide details and whether human prophylaxis starts at once. A blood antibody titre does not show whether the dog is infected.

Further reading: WOAH Terrestrial Animal Health Code

6 · Zoonoses: rabies, brucellosis, tuberculosis and anthrax · medium

In a brucellosis programme, the Rose Bengal test is followed by the complement fixation test only in Rose Bengal-positive animals. What is the effect of this series interpretation?

  1. Sensitivity increases and specificity decreases compared with either test used alone
  2. Both sensitivity and specificity increase
  3. Neither changes, because the two tests are independent and measure different antibodies
  4. Specificity increases and sensitivity decreases compared with either test alone
Answer and working

D. Specificity increases and sensitivity decreases compared with either test alone

Series testing (positive only if both are positive) raises specificity and lowers sensitivity. It is used to confirm reactors before slaughter. Because both are antibody tests, they are not fully independent and the gain is smaller than the formula predicts.

Further reading: Thrusfield M et al., Veterinary Epidemiology, 4th ed.

7 · Zoonoses: leptospirosis, glanders, KFD, avian influenza and Japanese encephalitis · hard

After severe floods, several rice farmers are admitted with fever, jaundice and kidney failure. Which zoonosis is the most likely cause?

  1. Brucellosis
  2. Kyasanur Forest disease
  3. Glanders
  4. Leptospirosis
Answer and working

D. Leptospirosis

Leptospires shed in rodent and livestock urine survive in flood water and wet soil. Fever with jaundice and renal failure is Weil's disease. Floods are a classic trigger for human leptospirosis clusters.

Further reading: Thrusfield M et al., Veterinary Epidemiology, 4th ed.

8 · Zoonoses: leptospirosis, glanders, KFD, avian influenza and Japanese encephalitis · medium

Why are H5 and H7 low pathogenicity avian influenza viruses in poultry a regulatory concern?

  1. They are always highly pathogenic for humans and spread readily from person to person after any exposure to poultry
  2. HPAI viruses have so far arisen only from H5 and H7 subtypes, which can mutate to high pathogenicity in poultry
  3. They cannot be detected by any laboratory test, so infected flocks go unnoticed until they die
  4. They infect only mammals
Answer and working

B. HPAI viruses have so far arisen only from H5 and H7 subtypes, which can mutate to high pathogenicity in poultry

HPAI has emerged from H5 and H7 LPAI precursors through changes at the haemagglutinin cleavage site during circulation in poultry, so these subtypes are monitored even when mild.

Further reading: WOAH Manual of Diagnostic Tests and Vaccines for Terrestrial Animals

9 · Measures of disease frequency: incidence, prevalence, morbidity, mortality and case fatality · easy

Point prevalence measured in a single cross-sectional survey is most useful for:

  1. Estimating the risk that a healthy animal will become diseased during the next month
  2. Estimating the current burden of disease to plan treatment or control work
  3. Measuring the speed at which new cases occur
  4. Measuring how often diseased animals die
Answer and working

B. Estimating the current burden of disease to plan treatment or control work

Prevalence describes how much disease exists at one time, useful for planning. Risk and speed of new cases are incidence measures; how often cases die is case fatality.

Further reading: Thrusfield M et al., Veterinary Epidemiology, 4th ed.

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Read the subject

Veterinary Epidemiology & ZoonosesThe full study manual, free Australasian Veterinary Examination, formerly the National Veterinary ExaminationFormat, sections and how it has changed

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Veterinary Epidemiology & Zoonoses for other exams

ENARE multiprofessional residency · BrazilSAVC Registration Examination · South AfricaICAR AICE-JRF/SRF · IndiaICAR AIEEA · IndiaEGEL Plus MVZ · MexicoNational Licensure Examination for Veterinarians · NepalENADE · BrazilNational Veterinary Examination · JapanNAVLE · USA / CanadaRCVS Statutory Membership Examination · UKAVMA ABVS-recognised specialty boards · USAEBVS European College diplomas · Europe

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