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ICAR AICE-JRF/SRF Veterinary Toxicology: practice questions

ICAR AICE-JRF/SRF (PhD) · India · NTA for ICAR

Original practice questions written to the published syllabus · not past papers
6worked here, free
30written to this exam in this subject
15syllabus units

What this subject covers

Poisoning by metals, plants, mycotoxins, pesticides, non-protein nitrogen, venoms and pollutants, with residues in food and the antidotes used.

In the exams: AVE Paper 1 toxicology at least 3; SAVC toxicology 10 (plus southern African plant poisonings); ICAR AIEEA-PG 13 Unit IV (poisonous plants, agro-chemicals); ICAR AICE-JRF core group 07

What ICAR AICE-JRF/SRF asks from it

ICAR AICE-JRF/SRF core group 07

Mechanisms at molecular level (VKOR, cytochrome oxidase, AChE aging, thiomolybdate chemistry, bioactivation of aflatoxin), toxicokinetics and species differences, ecotoxicology (diclofenac and vultures), residues, ADI and MRL derivation.

Where the 30 questions fall

How our questions for ICAR AICE-JRF/SRF spread across the units of Veterinary Toxicology. Difficulty: 0 easy, 17 medium, 13 hard.

Ecotoxicology and residues4
Metal toxicity: lead, arsenic and mercury3
Mycotoxins and aflatoxicosis3
Copper, molybdenum, fluorine and selenium toxicity2
Cyanogenic plants2
Nitrate and nitrite poisoning2
Organophosphate and carbamate poisoning2
Organochlorine and pyrethroid poisoning2
Urea and non-protein nitrogen toxicity2
Radiation hazards2
Antidotes2
Corrosives and irritants1
Oxalate, lantana and bracken poisoning1
Rodenticide poisoning1
Water-borne toxicities1

6 practice questions, worked

Choose an answer, then open the working. Each explanation says why the right answer is right and why the others are not.

1 · Nitrate and nitrite poisoning · hard

A forage contains 1% potassium nitrate (KNO3) on a dry-matter basis. What is its nitrate (NO3) content?

  1. About 1.64%
  2. About 0.61%
  3. About 0.14%
  4. About 0.23%
Answer and working

B. About 0.61%

NO3 is 62.0 of KNO3's 101.1 g/mol, i.e. 61.3%; 1% × 0.613 ≈ 0.61% NO3. 1.64% inverts the factor; 0.14% would be nitrate-N in KNO3.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

2 · Mycotoxins and aflatoxicosis · medium

Equine leukoencephalomalacia, liquefactive necrosis of cerebral white matter in horses, is caused by

  1. Aflatoxin B1 from Aspergillus flavus
  2. Ochratoxin A from Penicillium verrucosum
  3. Fumonisins from Fusarium verticillioides
  4. Lolitrem B from perennial ryegrass endophyte
Answer and working

C. Fumonisins from Fusarium verticillioides

Fumonisins disrupt sphingolipid metabolism and cause ELEM in horses and pulmonary oedema in pigs. Lolitrem B causes ryegrass staggers.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

3 · Organochlorine and pyrethroid poisoning · medium

Why are organochlorine insecticides such as DDT restricted internationally?

  1. They are rapidly hydrolysed to toxic gases in soil
  2. They are highly water-soluble and leach quickly into groundwater and wells
  3. They are acutely toxic only to mammals
  4. They persist, are stored in fat and biomagnify up food chains
Answer and working

D. They persist, are stored in fat and biomagnify up food chains

Lipophilic, persistent organochlorines bioaccumulate and biomagnify; the Stockholm Convention restricts them. Their low water solubility is the opposite of rapid leaching into groundwater.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

4 · Urea and non-protein nitrogen toxicity · hard

Urea contains 46.6% nitrogen. What is its crude protein equivalent?

  1. About 46.6%
  2. About 291%
  3. About 7.5%
  4. About 746%
Answer and working

B. About 291%

Crude protein = N × 6.25; 46.6 × 6.25 = 291%, so 1 kg urea supplies the nitrogen of about 2.9 kg crude protein. 46.6% is the nitrogen content, not protein; 7.5% divides by 6.25 instead of multiplying, and 746% multiplies by 16 (the N content of protein) instead of 6.25.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

5 · Antidotes · medium

Why is the calcium salt of EDTA used for lead poisoning, not disodium EDTA?

  1. Disodium EDTA does not bind lead
  2. The calcium salt crosses the blood-brain barrier and removes lead from the brain
  3. Disodium EDTA chelates blood calcium and causes hypocalcaemic tetany
  4. Disodium EDTA is only active orally
Answer and working

C. Disodium EDTA chelates blood calcium and causes hypocalcaemic tetany

Calcium disodium EDTA exchanges its calcium for lead; disodium EDTA would strip calcium from the blood.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

6 · Antidotes · hard

Sodium nitrite is used in cyanide poisoning because

  1. It donates sulfur to rhodanese
  2. Its methaemoglobin binds cyanide as cyanmethaemoglobin, freeing cytochrome oxidase
  3. It reduces cyanide to ammonia, which the liver converts to urea for excretion in urine
  4. It is a direct chelator of cyanide
Answer and working

B. Its methaemoglobin binds cyanide as cyanmethaemoglobin, freeing cytochrome oxidase

Methaemoglobin's ferric iron has high affinity for cyanide, drawing it off cytochrome oxidase; thiosulfate then allows rhodanese to form thiocyanate.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

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Read the subject

Veterinary ToxicologyThe full study manual, free ICAR AICE-JRF/SRFFormat, sections and how it has changed

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Veterinary Toxicology for other exams

ICAR AIEEA · IndiaENADE · BrazilNational Veterinary Examination · JapanBCSE · USA / CanadaNAVLE · USA / CanadaNational Licensure Examination for Veterinarians · Nepal

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