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National Licensure Examination for Veterinarians Veterinary Toxicology: practice questions

National Licensure Examination for Veterinarians (NLEV) · Nepal · Nepal Veterinary Council (NVC Act 2055 BS)

Original practice questions written to the published syllabus · not past papers
6worked here, free
20written to this exam in this subject
14syllabus units

What this subject covers

Poisoning by metals, plants, mycotoxins, pesticides, non-protein nitrogen, venoms and pollutants, with residues in food and the antidotes used.

In the exams: AVE Paper 1 toxicology at least 3; SAVC toxicology 10 (plus southern African plant poisonings); ICAR AIEEA-PG 13 Unit IV (poisonous plants, agro-chemicals); ICAR AICE-JRF core group 07

Where the 20 questions fall

How our questions for National Licensure Examination for Veterinarians spread across the units of Veterinary Toxicology. Difficulty: 18 easy, 2 medium, 0 hard.

Metal toxicity: lead, arsenic and mercury2
Copper, molybdenum, fluorine and selenium toxicity2
Oxalate, lantana and bracken poisoning2
Rodenticide poisoning2
Snake bite and insect stings2
Ecotoxicology and residues2
Cyanogenic plants1
Nitrate and nitrite poisoning1
Mycotoxins and aflatoxicosis1
Organophosphate and carbamate poisoning1
Organochlorine and pyrethroid poisoning1
Urea and non-protein nitrogen toxicity1
Water-borne toxicities1
Antidotes1

6 practice questions, worked

Choose an answer, then open the working. Each explanation says why the right answer is right and why the others are not.

1 · Mycotoxins and aflatoxicosis · easy

Aflatoxins are produced mainly by

  1. Claviceps purpurea
  2. Fusarium graminearum
  3. Aspergillus flavus and A. parasiticus
  4. Pithomyces chartarum
Answer and working

C. Aspergillus flavus and A. parasiticus

Aspergillus flavus and A. parasiticus produce aflatoxins on groundnuts, maize and cottonseed. Claviceps produces ergot; Fusarium graminearum zearalenone and deoxynivalenol.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

2 · Organophosphate and carbamate poisoning · easy

Organophosphates produce toxicity mainly by

  1. Inhibiting acetylcholinesterase
  2. Blocking GABA-A chloride channels
  3. Blocking vitamin K epoxide reductase
  4. Opening neuronal sodium channels
Answer and working

A. Inhibiting acetylcholinesterase

OPs phosphorylate acetylcholinesterase, so acetylcholine accumulates at synapses. GABA-A block is the action of cyclodiene organochlorines.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

3 · Rodenticide poisoning · easy

Tetanic extensor seizures triggered by noise or touch, with a 'sawhorse' stance, suggest poisoning by

  1. Warfarin
  2. Cholecalciferol
  3. Strychnine
  4. Arsenic
Answer and working

C. Strychnine

Strychnine antagonises glycine at spinal inhibitory synapses, so stimuli trigger extensor spasms. Metaldehyde seizures, in contrast, are not stimulus-induced.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

4 · Water-borne toxicities · easy

Groundwater naturally high in which element is a major livestock and human problem in parts of Bangladesh and West Bengal?

  1. Selenium
  2. Molybdenum
  3. Inorganic mercury
  4. Arsenic
Answer and working

D. Arsenic

Geogenic arsenic in shallow tube-well water affects people and livestock in the Bengal delta.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

5 · Ecotoxicology and residues · easy

LD50 is best defined as

  1. The statistical dose that kills 50% of a test group by a set route and time
  2. The lowest dose that kills any animal
  3. The dose that produces the intended therapeutic effect in 50% of treated animals
  4. The highest dose with no observed adverse effect
Answer and working

A. The statistical dose that kills 50% of a test group by a set route and time

LD50 is a quantal measure of acute lethality. The ED50 is the effective dose in 50%, and the highest dose without adverse effect is the NOAEL.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

6 · Ecotoxicology and residues · easy

The withdrawal period of a veterinary drug is

  1. The time a drug takes to reach peak plasma concentration after a single intramuscular dose
  2. The shelf life of the opened product
  3. Time from last dose until meat, milk or eggs are usable, with residues below the MRL
  4. The interval between doses
Answer and working

C. Time from last dose until meat, milk or eggs are usable, with residues below the MRL

The withdrawal (withholding) period is set so residues fall below the maximum residue limit; it applies to the labelled species, dose and route.

Further reading: Gupta, Veterinary Toxicology (3rd ed.); Merck Veterinary Manual, Toxicology

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Read the subject

Veterinary ToxicologyThe full study manual, free National Licensure Examination for VeterinariansFormat, sections and how it has changed

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Veterinary Toxicology for other exams

ICAR AIEEA · IndiaENADE · BrazilNational Veterinary Examination · JapanBCSE · USA / CanadaNAVLE · USA / CanadaICAR AICE-JRF/SRF · India

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