LAISHA
Open Laisha

Australasian Veterinary Examination, formerly the National Veterinary Examination General & Systemic Veterinary Pharmacology: practice questions

Australasian Veterinary Examination (AVE), formerly the National Veterinary Examination (NVE) · Australia / New Zealand · Australasian Veterinary Boards Council (AVBC)

Original practice questions written to the published syllabus · not past papers
10worked here, free
22written to this exam in this subject
12syllabus units

About Australasian Veterinary Examination, formerly the National Veterinary Examination

Australasian Veterinary Examination (AVE), formerly the National Veterinary Examination (NVE) is a licensing and registration exam run by Australasian Veterinary Boards Council (AVBC), for candidates in Australia / New Zealand. Step 2, preliminary MCQ exam: computer-adaptive, Rasch-scored, cut-score 500. Paper 1 (base knowledge) 80 Q in 120 min; Paper 2 (clinical reasoning) 80 Q in 150 min. Held once a year in April (next: 16 Apr 2027). Step 3, clinical exam: 5 days at the University of Queensland, usually November.

Source: avbc.asn.au.

Checked against the exam body's published information. Formats and fees change; confirm the current edition there before you book.

General & Systemic Veterinary Pharmacology in Australasian Veterinary Examination, formerly the National Veterinary Examination

How drugs move through and act on the body, how species differ, and the drugs used on each organ system.

Our 22 Australasian Veterinary Examination, formerly the National Veterinary Examination questions in this subject: 0 easy, 14 medium, 8 hard, across 12 units.

10 practice questions, worked

Choose an answer, then open the working. Each explanation says why the right answer is right and why the others are not.

These 10 were written to Australasian Veterinary Examination, formerly the National Veterinary Examination and are not shown on any other exam's page.

Question 1 · medium

Under Regulation (EU) 2019/6, when no product is authorised for a condition in a species, the veterinarian's first step down the cascade is to use:

  1. A human medicine imported from outside the EU
  2. A product compounded by a pharmacist for the case
  3. Any product the veterinarian judges most effective for the case, with no prescribed order of choice
  4. A veterinary product authorised in that or another member state for another species or condition
Answer and working

D. A veterinary product authorised in that or another member state for another species or condition

The cascade (Articles 112-114) is ordered: first a veterinary product authorised in that or another member state for another species or condition, then an EU-authorised human product, then an extemporaneous preparation; food-producing species have extra limits (MRL-listed substances, minimum withdrawal periods). Choosing freely ignores the legal order, which is the tempting error.

Question 2 · medium

Once-daily dosing of aminoglycosides is preferred because:

  1. Their killing is concentration-dependent and renal cortical uptake is saturable, so high infrequent peaks improve efficacy and reduce nephrotoxicity
  2. They are time-dependent drugs whose efficacy depends on staying above the MIC throughout the dosing interval, and a single large dose achieves this for 24 hours
  3. They have a very long half-life of several days
  4. They are eliminated mainly by the liver
Answer and working

A. Their killing is concentration-dependent and renal cortical uptake is saturable, so high infrequent peaks improve efficacy and reduce nephrotoxicity

Aminoglycosides are concentration-dependent (Cmax/MIC), have a post-antibiotic effect, and accumulate in the renal cortex by a saturable process. Beta-lactams are the time-dependent class; aminoglycosides have short half-lives and are excreted by glomerular filtration.

Question 3 · hard

In a horse with severe equine asthma, systemic atropine gives rapid bronchodilation but is not used for maintenance because it:

  1. Reduces gut motility and can cause ileus and colic
  2. Can cause severe bronchoconstriction after 24 hours
  3. Is not absorbed after intravenous injection
  4. Is a beta-2 antagonist
Answer and working

A. Reduces gut motility and can cause ileus and colic

Atropine blocks muscarinic tone throughout the body; in horses this commonly causes intestinal stasis and colic, and also tachycardia and mydriasis. Inhaled ipratropium avoids most systemic effects.

Question 4 · medium

Which emetic is generally more reliable in cats than apomorphine?

  1. An alpha-2 agonist such as dexmedetomidine
  2. 3% hydrogen peroxide
  3. Table salt
  4. Ipecac syrup
Answer and working

A. An alpha-2 agonist such as dexmedetomidine

Apomorphine is less effective in cats; alpha-2 agonists (xylazine, dexmedetomidine) are commonly used. Hydrogen peroxide causes haemorrhagic gastritis in cats and salt risks hypernatraemia.

Question 5 · medium

The first-choice drug class for treatment of equine gastric ulcer syndrome is:

  1. Antacids given once daily
  2. H1 antihistamines
  3. Proton pump inhibitors such as omeprazole
  4. Misoprostol alone
Answer and working

C. Proton pump inhibitors such as omeprazole

Omeprazole irreversibly inhibits the H-K-ATPase and gives sustained acid suppression. Antacids act briefly; H1 blockers do not affect acid; misoprostol has a role in some glandular disease but is not first-line alone.

Question 6 · hard

Liquid paraffin for a horse with large-colon impaction is given by nasogastric tube rather than by mouth because:

  1. It is inactivated by saliva
  2. Oral dosing risks aspiration, and aspirated oil causes lipid pneumonia
  3. The horse vomits it immediately
  4. It is absorbed in the stomach and would be ineffective by the time it reached the colon
Answer and working

B. Oral dosing risks aspiration, and aspirated oil causes lipid pneumonia

Mineral oil is tasteless and does not trigger swallowing reflexes well; aspiration causes severe pneumonia. Horses cannot vomit, and mineral oil is not absorbed, which is how it lubricates the colon.

Question 7 · hard

A male cat with functional urethral obstruction after relief of a urethral plug is given prazosin. The aim is to:

  1. Increase detrusor contraction
  2. Acidify the urine
  3. Relax the striated external urethral sphincter muscle directly
  4. Relax urethral smooth muscle by blocking alpha-1 receptors
Answer and working

D. Relax urethral smooth muscle by blocking alpha-1 receptors

Prazosin relaxes the smooth-muscle part of the urethra; the striated distal urethra in cats needs skeletal muscle relaxants. Bethanechol would target the detrusor.

Question 8 · medium

Trilostane is used to treat pituitary-dependent hyperadrenocorticism in dogs. Its mechanism is:

  1. Competitive inhibition of 3-beta-hydroxysteroid dehydrogenase
  2. Selective necrosis of the adrenal zona fasciculata and reticularis
  3. Blocking the glucocorticoid receptor
  4. Reducing ACTH release from the pituitary
Answer and working

A. Competitive inhibition of 3-beta-hydroxysteroid dehydrogenase

Trilostane reversibly inhibits steroid synthesis at 3-beta-HSD. Mitotane is the adrenocorticolytic drug that destroys the zona fasciculata and reticularis.

Question 9 · medium

A 1,000 mL bag is to run over 8 hours through a giving set that delivers 20 drops/mL. The drip rate is about:

  1. 125 drops/min
  2. 42 drops/min
  3. 6 drops/min
  4. 21 drops/min
Answer and working

B. 42 drops/min

Drops/min = 1,000 mL x 20 drops/mL / 480 min = 41.7. 125 drops/min is mL/h (1,000/8); 6 drops/min divides the hourly rate by the drop factor (125/20) instead of multiplying; 21 drops/min assumes a 10 drops/mL set.

Question 10 · hard

Hypertonic saline (7.2-7.5%) given to a hypovolaemic horse expands plasma volume mainly by:

  1. Drawing water from the interstitial and intracellular spaces into the vessels
  2. Remaining in the vessels because of its large molecules, like a colloid solution
  3. Stimulating the heart as a positive inotrope only
  4. Adding a large volume of fluid directly
Answer and working

A. Drawing water from the interstitial and intracellular spaces into the vessels

It is a small-volume fluid whose osmotic pull moves water into the plasma; the effect is short-lived unless followed by isotonic fluid or drinking water. Colloids, not crystalloids, rely on large molecules.

A study plan for General & Systemic Veterinary Pharmacology in Australasian Veterinary Examination, formerly the National Veterinary Examination

This plan follows where our questions actually fall, so the time goes where the marks are likely to be. It is our reading of the syllabus, not the exam body's weighting.

  1. First, the heavy units (64% of the 22 questions): Species differences in drug response (6, 27%); Drugs acting on the digestive system: ruminatorics and antacids (3, 14%); Fluids and electrolytes (3, 14%); Non-steroidal anti-inflammatory drugs (2, 9%).

    Read the manual chapters for these first and do every worked question you can find on them.

  2. Then the middle band: Autacoids and humoral agents (1, 5%); Drugs acting on the autonomic nervous system (1, 5%); Drugs acting on the cardiovascular system (1, 5%); Drugs acting on the respiratory system (1, 5%).

    Aim for one sitting per unit, then mixed questions across them.

  3. Then the lighter units: Drugs acting on the urogenital system (1, 5%); Endocrine pharmacology (1, 5%); Pharmacokinetics (1, 5%); Sources and nature of drugs (1, 5%).

    Learn the definitions, classifications and standard numbers; these units are more often recalled than worked.

  4. Leave time for the hard ones: Drugs acting on the respiratory system (1 hard of 1), Drugs acting on the urogenital system (1 hard of 1), Fluids and electrolytes (2 hard of 3).

    Come back to these after a first pass, untimed, and read every explanation, including for the options you rejected.

  5. Finish timed. Sit the subject as a timed set without notes, mark it, and send each wrong answer back to its unit above.

Last updated · How Laisha writes and checks its pages · Report a mistake

Ask Laisha about this

Opens Laisha's chat with your question ready to send. Sign in or start free.

Unlock every question — Australasian Veterinary Examination, formerly the National Veterinary Examination General

US$10 a month · one price worldwide · cancel any time

  • Every practice question in this subject, with full working
  • Timed exam papers and progress by unit
  • Ask Laisha to explain any answer — up to 1,000 questions a month
Free or Smarter
FreeSmarter
Grow guides, pest pages, articlesRead allRead all
Ask Laisha5 a dayUp to 1,000 a month
Exam practiceThe sample on each pageEvery question, timed papers
Crop calendar and pest alerts—For your own fields
Calculators and tools—All
Uploads and reports—100 a month, real files
10 days free for every new account, no card.