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National Veterinary Examination Systemic Veterinary Pathology: practice questions

National Veterinary Examination (獣医師国家試験) · Japan · Ministry of Agriculture, Forestry and Fisheries (MAFF), with the Veterinary Affairs Council

Original practice questions written to the published syllabus · not past papers
10worked here, free
33written to this exam in this subject
12syllabus units

What this subject covers

Lesions organ system by organ system, plus the pathology of nutritional and production diseases.

In the exams: ICAR AICE-JRF core group 06; ICAR AIEEA-PG 13 (Pathology)

What National Veterinary Examination asks from it

Philippines PRC, Nepal NLEV, China National Practising Veterinarian Examination and Korea National Veterinary Examination

Systemic lesions of pig and poultry diseases (atrophic rhinitis, enzootic pneumonia, pleuropneumonia, proliferative enteropathy, broiler ascites, Marek's disease nerve lesions) and core organ lesions of cattle and dogs.

Where the 33 questions fall

How our questions for National Veterinary Examination spread across the units of Systemic Veterinary Pathology. Difficulty: 11 easy, 19 medium, 3 hard.

Pathology of the respiratory system4
Pathology of the urinary system4
Pathology of the cardiovascular system3
Pathology of the liver3
Pathology of the musculoskeletal system3
Pathology of the skin3
Pathology of the reproductive system3
Pathology of the gastrointestinal tract2
Pathology of the nervous system2
Pathology of the endocrine system2
Nutritional pathology2
Production pathology2

10 practice questions, worked

Choose an answer, then open the working. Each explanation says why the right answer is right and why the others are not.

1 · Pathology of the cardiovascular system · easy

Which disease is the most common cause of fibrinous 'bread-and-butter' pericarditis in adult cattle?

  1. Myxomatous valve degeneration
  2. Hypertrophic cardiomyopathy
  3. White muscle disease
  4. Traumatic reticulopericarditis
Answer and working

D. Traumatic reticulopericarditis

A swallowed wire penetrates the reticulum, diaphragm and pericardium, carrying bacteria that cause fibrinopurulent pericarditis. Myxomatous valve degeneration is a canine valvular disease; white muscle disease affects the myocardium, not the pericardium.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

2 · Pathology of the cardiovascular system · medium

A 9-year-old cat is found with sudden painful paralysis of both hind limbs, cold pads and absent femoral pulses. At necropsy the left atrium is dilated and contains a thrombus. What is the most likely underlying heart disease?

  1. Myxomatous mitral valve degeneration
  2. Hypertrophic cardiomyopathy
  3. Patent ductus arteriosus (PDA)
  4. Arrhythmogenic right ventricular cardiomyopathy
Answer and working

B. Hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy is the commonest feline heart disease; left atrial dilation and stasis produce a thrombus that embolises to the aortic bifurcation (saddle thrombus). Myxomatous mitral degeneration is the classic disease of old small-breed dogs, and ARVC is a disease of Boxers affecting the right ventricle.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

3 · Pathology of the cardiovascular system · hard

At necropsy of a 7-year-old dog from a heartworm-endemic area, the laboratory's reference ratio of left ventricular free wall thickness to right ventricular free wall thickness is about 3:1. The measured left ventricular free wall is 12 mm and the right ventricular free wall is 8 mm. What do the ratio and the likely cause indicate?

  1. Ratio 1.5:1, left ventricular concentric hypertrophy from congenital subaortic stenosis in a large breed
  2. Ratio 0.67:1, normal wall thickness for a large dog
  3. Ratio 4:1, left ventricular hypertrophy from systemic hypertension
  4. Ratio 1.5:1, right ventricular hypertrophy from pulmonary hypertension due to Dirofilaria immitis
Answer and working

D. Ratio 1.5:1, right ventricular hypertrophy from pulmonary hypertension due to Dirofilaria immitis

12 mm / 8 mm = 1.5, so the ratio is 1.5:1, well below the reference of about 3:1: the right wall is relatively thick. Heartworms cause villous endarteritis of the pulmonary arteries, pulmonary hypertension and right ventricular pressure overload. Dividing the right wall by the left (8/12 = 0.67) inverts the ratio and hides the change; left ventricular hypertrophy would raise the ratio above 3:1 (as in the 4:1 option), not lower it.

Further reading: Maxie MG, Jubb, Kennedy and Palmer's Pathology of Domestic Animals, 6th ed.

4 · Pathology of the respiratory system · medium

A lung that is heavy, rubbery, fails to collapse when the chest is opened and bears rib impressions most likely has:

  1. Suppurative bronchopneumonia
  2. Embolic pneumonia
  3. Interstitial pneumonia
  4. Atelectasis
Answer and working

C. Interstitial pneumonia

Diffuse damage to alveolar walls in interstitial pneumonia makes the lung firm and elastic so it does not collapse and takes rib impressions. Bronchopneumonia is cranioventral and consolidated, embolic pneumonia is multifocal, and atelectatic lung is collapsed and sunken.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

5 · Pathology of the liver · medium

A sheep dies suddenly with jaundice, dark red urine and gunmetal-blue kidneys after being moved and handled. The ration contained supplementary minerals formulated for cattle. The most likely diagnosis is:

  1. Chronic copper poisoning with haemolytic crisis
  2. Acute leptospirosis
  3. Babesiosis transmitted by ticks at the new pasture
  4. Acute fasciolosis
Answer and working

A. Chronic copper poisoning with haemolytic crisis

Sheep store copper in the liver; stress triggers release, intravascular haemolysis and haemoglobinuric nephrosis that colours the kidneys dark blue-black. Cattle minerals are often too rich in copper for sheep. Acute fasciolosis causes haemorrhagic liver tracks and anaemia, not haemoglobinuria.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

6 · Pathology of the nervous system · medium

A ewe fed poor-quality silage circles to one side, has a drooping ear and lip on one side, and dies. Microabscesses in the brainstem are found on histology. The cause is:

  1. Listeria monocytogenes
  2. Histophilus somni (TEME)
  3. Coenurus cerebralis cyst
  4. Clostridium perfringens type D
Answer and working

A. Listeria monocytogenes

Listeria enters via the trigeminal nerve and produces brainstem microabscesses with cranial nerve deficits and circling. Histophilus somni causes thrombotic haemorrhagic infarcts in cattle; Coenurus forms a cyst that compresses the cerebrum; type D epsilon toxin causes symmetrical malacia.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

7 · Pathology of the skin · medium

A 1-year-old dog has a solitary, hairless, red, button-like dome on the pinna that appeared within weeks. Cytology shows round cells with moderate cytoplasm and many lymphocytes. The most likely diagnosis and outlook are:

  1. High-grade mast cell tumour, likely to metastasise widely
  2. Squamous cell carcinoma, locally invasive
  3. Cutaneous histiocytoma, likely to regress spontaneously
  4. Melanoma, likely malignant
Answer and working

C. Cutaneous histiocytoma, likely to regress spontaneously

Histiocytoma is a benign Langerhans cell tumour of young dogs and regresses as lymphocytes infiltrate it. Mast cell tumours have metachromatic granules on cytology and occur in older dogs; squamous cell carcinoma arises in sun-damaged, unpigmented skin.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

8 · Pathology of the reproductive system · medium

An 8-year-old intact bitch, 6 weeks after oestrus, is lethargic and polydipsic with a vulval discharge. The uterus is distended with pus. The hormonal state that predisposes to this condition is:

  1. Oestrogen deficiency in anoestrus after ovarian atrophy
  2. Excess prolactin in lactation
  3. Testosterone excess from ovarian tumour
  4. Prolonged progesterone dominance in dioestrus
Answer and working

D. Prolonged progesterone dominance in dioestrus

Repeated progesterone exposure causes cystic endometrial hyperplasia, closes the cervix and suppresses uterine immunity, allowing bacteria such as E. coli to cause pyometra. Oestrogen alone in the normal cycle does not produce this complex, though exogenous oestrogen given during dioestrus can increase the risk.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

9 · Pathology of the reproductive system · easy

Canine transmissible venereal tumour spreads between dogs by:

  1. Transplantation of living tumour cells during mating or licking
  2. A retrovirus carried in semen that integrates into the host's genital epithelium
  3. A papillomavirus in the vagina
  4. A bacterial toxin that transforms epithelium
Answer and working

A. Transplantation of living tumour cells during mating or licking

Canine transmissible venereal tumour is a clonal cell line passed as living cells from dog to dog, not a virus-induced tumour. Papillomaviruses cause warts in dogs but not this round-cell tumour.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

10 · Nutritional pathology · easy

Exudative diathesis, with green-blue subcutaneous oedema on the breast and abdomen of chicks, is caused by deficiency of:

  1. Vitamin K
  2. Vitamin E and selenium
  3. Thiamine
  4. Biotin
Answer and working

B. Vitamin E and selenium

Oxidative damage to capillary walls from lack of vitamin E and selenium lets plasma leak into subcutaneous tissue. Vitamin K deficiency causes haemorrhage rather than protein-rich oedema.

Further reading: Zachary JF, Pathologic Basis of Veterinary Disease, 7th ed.

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Read the subject

Systemic Veterinary PathologyThe full study manual, free National Veterinary ExaminationFormat, sections and how it has changed

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Systemic Veterinary Pathology for other exams

ASRB NET and ARS / SMS / STO · IndiaENADE · BrazilRPSC Veterinary Officer · IndiaTNPSC Animal Husbandry & Veterinary Science, Code 396 · IndiaAustralasian Veterinary Examination, formerly the National Veterinary Examination · Australia / New ZealandBCSE · USA / CanadaNAVLE · USA / CanadaPAVE and its QSE · USARCVS Statutory Membership Examination · UK

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