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ICAR AICE-JRF/SRF Systemic Veterinary Pathology: practice questions

ICAR AICE-JRF/SRF (PhD) · India · NTA for ICAR

Original practice questions written to the published syllabus · not past papers
10worked here, free
15written to this exam in this subject
12syllabus units

About ICAR AICE-JRF/SRF

ICAR AICE-JRF/SRF (PhD) is a PhD, fellowship and lectureship exam run by NTA for ICAR, for candidates in India. Computer-based, 2 hours, 120 questions: Part A 20 (general agriculture, animal husbandry, current events), Part B 50 (core group), Part C 50 (specialised subject). +4 / -1, maximum 480.

Source: icar.org.in.

Checked against the exam body's published information. Formats and fees change; confirm the current edition there before you book.

Systemic Veterinary Pathology in ICAR AICE-JRF/SRF

One-line recall of synonyms and named lesions: nutmeg liver, tiger heart, mulberry heart, bread-and-butter heart, morocco-leather abomasum, milk spots, pipestem liver, rubber jaw, big head, white-spotted kidney, gunmetal kidney; which organism or deficiency causes which lesion; pneumonia patterns; inclusion bodies and where to find them; nutritional deficiency diseases by species.

Lesions organ system by organ system, plus the pathology of nutritional and production diseases.

Our 15 ICAR AICE-JRF/SRF questions in this subject: 0 easy, 10 medium, 5 hard, across 12 units.

10 practice questions, worked

Choose an answer, then open the working. Each explanation says why the right answer is right and why the others are not.

These 10 were written to ICAR AICE-JRF/SRF and are not shown on any other exam's page.

Question 1 · medium

Acute bovine pulmonary oedema and emphysema (fog fever) after a move to lush pasture is caused by:

  1. Nitrate converted to nitrite in the rumen, forming methaemoglobin
  2. Hypersensitivity to mould spores in hay
  3. Perilla ketone from purple mint
  4. 3-methylindole formed in the rumen from L-tryptophan
Answer and working

D. 3-methylindole formed in the rumen from L-tryptophan

Rumen microbes convert L-tryptophan in lush grass to 3-methylindole, which is activated by club cells and damages type I pneumocytes. Mould spores cause hypersensitivity pneumonitis (farmer's lung) in housed cattle; nitrite causes methaemoglobinaemia, not interstitial pneumonia. Perilla ketone produces a similar lesion but is a plant toxin, not the fog fever mechanism.

Question 2 · hard

Random multifocal hepatic necrosis in a newborn foal with no zonal pattern is best explained by:

  1. Hypoxia from congenital heart failure, producing necrosis around the central veins
  2. Blood-borne infection such as Tyzzer's disease or equine herpesvirus 1
  3. Pyrrolizidine alkaloid poisoning
  4. Hepatic lipidosis from maternal undernutrition
Answer and working

B. Blood-borne infection such as Tyzzer's disease or equine herpesvirus 1

Randomly scattered necrotic foci mean organisms arrived by blood and grew wherever they lodged; Clostridium piliforme (Tyzzer's disease) and equine herpesvirus 1 are classic in foals. Hypoxia gives centrilobular necrosis, and pyrrolizidine poisoning is chronic with fibrosis and megalocytes.

Question 3 · medium

In most dogs with renal amyloidosis amyloid is glomerular, but in Abyssinian cats and Shar-Pei dogs it is deposited mainly in:

  1. The renal pelvis urothelium
  2. The glomerular mesangium only, as in other dogs
  3. The renal medullary interstitium
  4. The walls of the ureters
Answer and working

C. The renal medullary interstitium

Familial amyloidosis of Abyssinian cats and Shar-Pei dogs is mainly medullary interstitial, so these animals present with renal failure and papillary necrosis with less proteinuria. Glomerular deposition, typical of other dogs, causes heavy proteinuria and nephrotic syndrome.

Question 4 · medium

Laminar cortical necrosis in a feedlot steer that autofluoresces under ultraviolet light (about 365 nm) is typical of:

  1. Thromboembolic meningoencephalitis
  2. Listeriosis
  3. Bovine spongiform encephalopathy
  4. Polioencephalomalacia
Answer and working

D. Polioencephalomalacia

Polioencephalomalacia (thiamine disruption, high sulphur, lead) causes laminar necrosis of the cerebral cortex, and affected areas often fluoresce under a UV lamp. TEME gives haemorrhagic foci and BSE shows grey matter vacuolation without necrosis.

Question 5 · hard

Enzootic ataxia (swayback) of lambs is caused by maternal deficiency of:

  1. Copper
  2. Selenium
  3. Cobalt
  4. Vitamin A
Answer and working

A. Copper

Copper-dependent enzymes are needed for myelin formation; deficiency in the ewe causes cerebral white matter cavitation (congenital form) or spinal tract degeneration (delayed form) in lambs. Selenium deficiency causes white muscle disease, not demyelination.

Question 6 · medium

Ballooning degeneration of keratinocytes with intracytoplasmic eosinophilic inclusion bodies is characteristic of infection with:

  1. Papillomaviruses
  2. Poxviruses
  3. Herpesviruses
  4. Foot-and-mouth disease virus
Answer and working

B. Poxviruses

Poxviruses replicate in the cytoplasm, producing Bollinger (or Borrel) bodies, and cause ballooning degeneration. Herpesviruses form intranuclear inclusions; foot-and-mouth disease virus causes vesicles without inclusion bodies.

Question 7 · medium

Multifocal non-suppurative encephalitis with necrosis and myocarditis in an aborted 5-month bovine fetus most strongly suggests:

  1. Neospora caninum
  2. Brucella abortus
  3. Leptospira hardjo
  4. Aspergillus fumigatus
Answer and working

A. Neospora caninum

Neospora caninum is a major cause of bovine abortion worldwide, and its fetal brain and heart lesions are characteristic. Aspergillus causes placentitis and fetal ringworm-like skin lesions; Brucella's main lesion is placental.

Question 8 · medium

Islet amyloidosis in diabetic cats is formed from:

  1. Serum amyloid A (AA amyloid)
  2. Islet amyloid polypeptide (amylin)
  3. Immunoglobulin light chains
  4. Transthyretin
Answer and working

B. Islet amyloid polypeptide (amylin)

Amylin is co-secreted with insulin by beta cells and, in cats as in human type 2 diabetes, forms amyloid in islets that contributes to beta-cell loss. Serum amyloid A forms reactive (AA) amyloid in kidneys and liver; light chains form AL amyloid in plasma-cell tumours.

Question 9 · medium

Ovine white liver disease is a hepatic lipidosis of lambs associated with deficiency of:

  1. Copper
  2. Selenium
  3. Iodine
  4. Cobalt
Answer and working

D. Cobalt

Rumen microbes need cobalt to make vitamin B12; B12 is a cofactor for methylmalonyl-CoA mutase, needed to use propionate, and deficiency leads to fatty liver and wasting. Copper deficiency causes swayback and achromotrichia, not white liver.

Question 10 · hard

A broiler from a flock with high mortality has a right ventricle weighing 1.8 g and a total ventricular weight (right ventricle plus left ventricle plus septum) of 5.0 g. Using the widely used threshold of 0.28 for the right ventricle to total ventricle ratio, what is the ratio and the interpretation?

  1. 0.56, above 0.28, consistent with pulmonary hypertension
  2. 0.36, above 0.28, consistent with pulmonary hypertension
  3. 0.36, below 0.28, normal
  4. 2.78, calculated as total over right, indicating normal hearts
Answer and working

B. 0.36, above 0.28, consistent with pulmonary hypertension

RV:TV = 1.8/5.0 = 0.36, which exceeds 0.28 and indicates right ventricular hypertrophy from pulmonary hypertension (ascites syndrome). Dividing by left ventricle plus septum only (1.8/3.2 = 0.5625) uses the wrong denominator, and 5.0/1.8 = 2.78 inverts the ratio.

A study plan for Systemic Veterinary Pathology in ICAR AICE-JRF/SRF

This plan follows where our questions actually fall, so the time goes where the marks are likely to be. It is our reading of the syllabus, not the exam body's weighting.

  1. First, the heavy units (47% of the 15 questions): Nutritional pathology (2, 13%); Pathology of the liver (2, 13%); Pathology of the nervous system (2, 13%); Pathology of the cardiovascular system (1, 7%).

    Read the manual chapters for these first and do every worked question you can find on them.

  2. Then the middle band: Pathology of the endocrine system (1, 7%); Pathology of the gastrointestinal tract (1, 7%); Pathology of the musculoskeletal system (1, 7%); Pathology of the reproductive system (1, 7%).

    Aim for one sitting per unit, then mixed questions across them.

  3. Then the lighter units: Pathology of the respiratory system (1, 7%); Pathology of the skin (1, 7%); Pathology of the urinary system (1, 7%); Production pathology (1, 7%).

    Learn the definitions, classifications and standard numbers; these units are more often recalled than worked.

  4. Leave time for the hard ones: Pathology of the musculoskeletal system (1 hard of 1), Production pathology (1 hard of 1), Nutritional pathology (1 hard of 2).

    Come back to these after a first pass, untimed, and read every explanation, including for the options you rejected.

  5. Finish timed. Sit the subject as a timed set without notes, mark it, and send each wrong answer back to its unit above.

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